Global Consortium for Chemosensory Research (GCCR) is a diverse group of scientists, clinicians, patient advocates, and community partners that formed during the COVID-19 pandemic in March 2020. Members are distributed across 30 countries on five continents.
How prevalent is smell loss during COVID-19? Is COVID-19 related smell loss greater than smell loss due to other viral or respiratory illnesses? We predict that self-reported smell ability for respondents with COVID-19 will be lower than that of respondents without illness or those with other viral or respiratory illnesses.
This questionnaire includes items on smell, taste and chemesthesis function, as well as the collection of information on COVID-19 diagnosis. We also ask about COVID-19 symptoms, other viral and respiratory illness symptoms, other medical conditions, smoking, and medicine use. This will allow us to draw conclusions about how important the reports of loss of smell are relative to other symptoms of COVID-19 and if reports of loss of smell can aid in distinguishing between COVID-19 and other illnesses. Collecting data globally has the advantage of a large sample size and a reduced influence of local factors.
Arabic, Assamese, Bengali, Chinese (simplified), Chinese (traditional), Dutch, Danish, English, French, Finnish, German, Gujarati, Greek, Hebrew, Hind, Italian, Japanese, Kannada, Malayalam, Marathi, Oriya, Portuguese, Punjabi, Russian, Spanish, Swedish, Slovene, Turkish, Tamil, Telugu, Urdu
Details of the questionnaire can be found on our OSF page. Here we describe our planned data processing, statistical tests for hypothesis testing and exploratory analyses. You may also find the preregistration of this study there. You can download simulated data there. Data analysis scripts are available and anonymised data will also be made public there.
You can take the questionnaire on this page.
The gold standard for taste and smell loss testing is done in clinics with extensive test batteries. Self-reporting taste and smell ability shows only moderate agreement with those objective tests. Under the current challenge of social distancing we are developing an at home taste and smell assessment protocol to have more sensitive data on changes in taste and smell ability over time, in particular during COVID-19.
More details on home-test to be announced soon
R. Pellegrino, K. W. Cooper, A. Di Pizio, S. Bhutani, V. Parma, (2020) Coronaviruses and the Chemical Senses: Past, Present, and Future. doi: doi.org/10.1093/chemse/bjaa031
LitCovid is a curated literature hub for tracking up-to-date scientific information about the 2019 novel Coronavirus.
* Pre-prints are not peer reviewed, which means that other scientists have not evaluated the quality of the research and the validity of the conclusions. Such publications should be interpreted with caution.
GCCR (2020) More than just smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. doi: 10.1101/2020.05.04.20090902v2
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